Interest in medical therapy for PE is rapidly increasing among urologists, psychiatrists, endocrinologists and primary care physicians. Despite this, scientific research in this area is limited by the lack of reliable questionnaires and small numbers of randomized controlled trials.
Paroxetine is an antidepressant that blocks serotonin transporters in the brain. A clinical study found that paroxetine taken on a daily basis plus tadalafil (Viagra) as needed three to four hours before sexual intercourse could delay ejaculation.
Dosage
Although the US FDA has not specifically approved drugs to treat PE, several have been utilized safely and successfully. Paroxetine, a selective serotonin reuptake inhibitor, is one of them. It increases the amount of serotonin in the brain and delays ejaculation. This is why it’s useful for treating PE.
A study involving 100 men with lifelong PE found that daily 20-mg paroxetine improved intravaginal ejaculatory latency time (IELT) by a significant amount. The study was designed to assess the effect of paroxetine on IELT and sexual performance, both in combination with tadalafil and alone.
This quasi-experimental study was performed on males ranging in age from 17 to 49 years and was conducted in a clinical setting. All participants were married and had a history of lifelong PE with an IELT that was shorter than 1.5 minutes.
Those who were given daily paroxetine treatment for four weeks exhibited an improvement in their IELT. Those who remained with this group were then treated on an ‘on demand’ basis. This group had a mean IELT of 4.5 minutes in over 600 intercourses over the next six months.
While a prescription is required to obtain paroxetine, it’s much more accessible than other medications used for PE. Priligy, another antidepressant that works similarly to paroxetine, can only be obtained via a doctor and isn’t suitable for those with heart problems or certain drug interactions.
Side effects
While PE may be triggered by sexual stress and anxiety, it is a treatable condition. PE can be treated with a variety of medications, including SSRIs. These drugs inhibit the serotonin reuptake in the brain and increase its levels, which helps delay ejaculation. Paroxetine is a type of SSRI and it has been shown to help with PE. It can be taken on a daily basis or on-demand, just prior to intercourse. This can significantly increase ejaculation latency times and improve the quality of sex.
Premature ejaculation is a significant problem for many men and can cause stress, anxiety, or even damage relationships. It can also interfere with sexual pleasure and can lead to an inability to orgasm. PE is typically caused by a number of factors, including depression, PTSD, and other mental health issues, underlying medical conditions, and genetic mutations (including polymorphisms of the serotonin transporter).
While many people have tried to treat PE with Kegel exercises and other behavioral changes, medication is the most effective treatment option. This is especially true for those with a severe case of PE. Several studies have shown that SSRIs can dramatically increase ejaculation latency times. A meta-analysis of 35 studies found that paroxetine was the most effective of the SSRIs studied. SSRIs are also very safe, easy to take, and well-tolerated.
Precautions
Paroxetine isn’t FDA-approved for treating PE, but many doctors prescribe it off-label. This means that the doctor is using their professional judgment to believe that the medication may be useful for this purpose. This is a common practice in medicine, and is not considered illegal.
When taking Paxil for PE, it is important to follow the instructions on your prescription. You should not increase or decrease your dosage without consulting with your doctor first. Also, make sure to take the pill at least a few hours before you have sexual intercourse. This will help prevent your ejaculation from occurring before the start of sexual intercourse.
Selective serotonin reuptake inhibitors, such as paroxetine, can be used to treat PE by blocking the transporters that normally recycle serotonin back into brain cells after it is released. This increases serotonin levels in the micro neuronal milieu and activates post-synaptic receptors. These actions can delay ejaculation and prevent orgasm.
Premature ejaculation is a frustrating problem that can lead to poor sex and intimacy. It is believed to be caused by a combination of factors, including psychological problems, somatic disorders, and neurobiological disturbances. Several medications have been used to treat PE, with the most successful being SSRIs. However, these aren’t always effective in some people, especially those with underlying medical conditions. For these reasons, researchers are continuing to study the effectiveness of a variety of medications for PE.
Warnings
Premature ejaculation (PE) is a sexual dysfunction that affects men of all ages. PE is often caused by stress, anxiety, or underlying mental health issues. PE can cause sexual problems and negatively impact relationships. There are many treatment options available for PE, including Kegel exercises and a variety of medications. Paroxetine is an FDA-approved medication that can be used to treat PE.
Paxil is an antidepressant that can be used to treat a variety of conditions, including anxiety and depression. It has also been shown to help with PE in recent studies. The study involved giving 61 males either daily paroxetine or ‘on demand’ paroxetine three to four hours before sexual intercourse. The results showed that ‘on demand’ paroxetine was just as effective at treating PE as daily treatment. The researchers suggest that patients who are unwilling to use SSRIs on a daily basis for PE could benefit from using paroxetine on an as-needed basis.
However, it is important to note that this medication can increase the risk of serotonin syndrome poisoning if taken in conjunction with MAO inhibitors. MAO inhibitors are a type of drug that inhibit the breakdown of serotonin in the body. In addition, this medication can cause a variety of side effects, including drowsiness and dizziness. If these side effects occur, you should contact a doctor immediately.
